Complex genetic disorder that can be influenced by both maternal and fetal DNA.
Genetic factors
- Genome-wide association studies (GWAS)GWAS have identified genetic loci associated with preeclampsia. These loci include genes that are involved in blood pressure, placental development, and kidney function.
- Polygenic risk scoreA polygenic risk score for hypertension has been associated with preeclampsia.
- DNA methylationDNA methylation can change in pregnancy and other conditions, which can alter how genes are regulated.
Other factors
- Environmental exposuresAge and weight can determine whether genetic variants result in preeclampsia.
- InheritancePreeclampsia can follow Mendelian patterns of inheritance in some families. However, the inheritance pattern is unknown in many families.
Overall impact
Preeclampsia is a serious complication of pregnancy that affects both the mother and the fetus. It’s also known as toxemia.
Future research
Future research is needed to better understand the genetic architecture of preeclampsia and to develop new treatments.
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